Polyclonal Antibodies - Phospho-SHP-1 (Tyr564) Rabbit Polyclonal Antibody

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Phospho-SHP-1 (Tyr564) Rabbit Polyclonal Antibody

Catalog #：EAB10859

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB10859-30UL	In Stock	30ul	￡119.90
EAB10859-100UL	In Stock	100ul	￡251.90
EAB10859-200UL	In Stock	200ul	￡405.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, ELISA
Species Reactivity	Human, Monkey
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	68
Conjugate	Unconjugate
Specificity	Phospho-SHP-1 (Tyr564) Rabbit Polyclonal Antibody detects endogenous levels of SHP-1 protein only when phosphorylated at Tyr564.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Protein tyrosine phosphatase non-receptor type 6; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1; PTPN6
Gene Aliases	PTPN6
UniProt ID	P29350
Entrez Gene ID	5777

Product Description

SHP-1 also known as SH-PTP1, PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. SHP-1 plays a crucial role in regulating cellular signaling pathways by dephosphorylating tyrosine residues on target proteins, which is essential for maintaining the balance of tyrosine phosphorylation in cells. This regulation is particularly important in hematopoietic cells, where SHP-1 modulates the activity of various signaling pathways involved in cell growth, differentiation, and immune responses. The presence of two SH2 domains in SHP-1 enables interaction with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby influencing the downstream signaling events that are critical for cellular function.

Product Image Gallery
Western blot analysis of extracts on COS7 cells treated with EGF, using Phospho-SHP-1 (Tyr564) Rabbit Polyclonal Antibody (EAB10859) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol