Q05586

NMDAR1 also known as NMDAζ1, GRIN1 plays a crucial role in mediating excitatory neurotransmission in the brain, which is essential for processes such as learning, memory, and synaptic plasticity. NMDAR1 is primarily located in the postsynaptic membrane of neurons, where NMDAR1 forms part of the NMDA receptor complex, allowing for calcium ion influx in response to glutamate binding. The unique structure of NMDA receptors, which includes a high permeability to calcium ions, is vital for their function in synaptic signaling and plasticity, as calcium influx activates various intracellular signaling pathways that influence neuronal function and survival.