Q02750

MEK1 also known as MKK1, MAP2K1 is a member of the dual specificity protein kinase family. MEK1 plays a crucial role in the MAPK signaling pathway, which is essential for regulating various cellular processes such as proliferation, differentiation, and survival. MEK1 is primarily located in the cytoplasm and is activated in response to growth factors and other extracellular signals, leading to translocation to the nucleus where MEK1 phosphorylates and activates extracellular signal-regulated kinases (ERKs). This activation is vital for the transmission of signals from the cell surface to the nucleus, ultimately influencing gene expression and cellular responses. MEK1 interaction with other proteins in the MAPK pathway, such as RAS and RAF, underscores MEK1′s importance in cellular signaling and potential implications in cancer and other diseases.