Glut3 also known as SLC2A3 is a transporter protein regulating glucose transport across cell membranes and is a primary glucose transporter in neurons. Glut3 plays a critical role in glucose transport, particularly in the brain, where Glut3 is predominantly expressed. This high-affinity glucose transporter is essential for maintaining glucose homeostasis in neuronal tissues, as neurons rely heavily on glucose as their primary energy source. Glut3′s ability to facilitate rapid glucose uptake is vital for supporting the high metabolic demands of the brain, especially during periods of increased activity or stress. Understanding Glut3 function is crucial, as dysregulation of glucose transport can lead to various neurological disorders and metabolic diseases.