Monoclonal Antibodies - ERCC1 Mouse Monoclonal Antibody

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ERCC1 Mouse Monoclonal Antibody

Catalog #：EAB14695

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14695-30UL	In Stock	30ul	￡97.90
EAB14695-100UL	In Stock	100ul	￡218.90
EAB14695-200UL	In Stock	200ul	￡372.90

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IHC-P=1:100-500　 IF=1:100-500
MW (kDa)	33
Conjugate	Unconjugate
Specificity	ERCC1 Mouse Monoclonal Antibody detects endogenous levels of ERCC1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Excision Repair Cross Complementing 1; COFS4; ERCC-1; RAD10; UV20; ERCC1
Gene Aliases	ERCC1
UniProt ID	P07992
Entrez Gene ID	2067

Product Description

ERCC1 plays a crucial role in the nucleotide excision repair pathway, which is essential for maintaining genomic stability by repairing DNA damage caused by ultraviolet light and other environmental factors. ERCC1 forms a heterodimer with XPF, another key player in this repair process, and together they function as a structure-specific endonuclease that incises damaged DNA. This incisional activity is vital for the removal of bulky DNA adducts, thereby preventing mutations that could lead to skin cancer and other genetic disorders. The significance of ERCC1 in DNA repair highlights its potential as a biomarker for cancer susceptibility and as a target for therapeutic interventions aimed at enhancing DNA repair mechanisms in affected individuals.

Product Image Gallery

Western blot analysis of extracts on different cells, using ERCC1 Mouse Monoclonal Antibody (EAB14695) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Lane1: HepG2
Lane2: Jurkat
Lane3: 293T

Predicted band size: 33 kDa; Observed band size: 36 kDa

Immunohistochemical analysis of paraffin-embedded Human lung caricnoma tissue, using ERCC1 Mouse Monoclonal Antibody (EAB14695) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol