Q9UMD9

COL17A1 also known as Collagen type XVII alpha, BP180 is a collagen family hemidesmosome anchorage molecule of basal keratinocytes that promotes stable epidermal-dermal adhesion and wound healing. COL17A1 is critical for maintaining keratocyte and hair follicle stem cells, promoting cell motility and increased self-renewing capability. The protein functions by organizing actin and keratin filament networks via its interaction with intracellular scaffold protein plectin (PLEC) and integrin β4 in the hemidesmosomes. High expression of COL17A1 is associated with cervical, colorectal, pancreatic, and lung cancers. It induces a tumor-favorable microenvironment and promotes invasion and metastasis.