Recombinant Antibodies - GTBP/MSH6 Rabbit Monoclonal Antibody

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GTBP/MSH6 Rabbit Monoclonal Antibody

Catalog #：EAB21242

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21242-100UL	In Stock	100ul	￡251.90

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IHC-P=1:100-500　 IF/ICC=1:50-200
MW (kDa)	153
Conjugate	Unconjugate
Specificity	GTBP/MSH6 Rabbit Monoclonal Antibody detects endogenous levels of GTBP/MSH6 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	MutS homolog 6; GTBP; HSAP; p160; GTMBP; MSH-6; HNPCC5; LYNCH5; MMRCS3; MSH6
Gene Aliases	MSH6
UniProt ID	P52701
Entrez Gene ID	2956

Product Description

MSH6 also known as GTBP is a member of the DNA mismatch repair MutS family. MSH6 plays a crucial role in DNA mismatch repair pathway, which maintains genomic stability by correcting DNA replication errors. MSH6 is primarily located in the nucleus, where MSH6 forms a heterodimer with MSH2 to recognize and bind to G/T mismatches in DNA. This interaction initiates a cascade of events leading to excision and resynthesis of erroneous DNA segments. MSH6′s importance in this pathway is underscored by MSH6′s association with hereditary nonpolyposis colorectal cancer (HNPCC), where mutations in mismatch repair genes lead to microsatellite instability and increased cancer risk.

Product Image Gallery
Western blot analysis of extracts on Hela, Mouse lung cells, using GTBP/MSH6 Rabbit Monoclonal Antibody (EAB21242) at 1:2000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Predicted band size: 153 kDa; Observed band size: 170 kDa

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol