Q9UBC3

Dnmt3b plays a crucial role in the regulation of gene expression through DNA methylation, a process vital for normal development and cellular differentiation. Specifically, Dnmt3b is responsible for de novo methylation, which establishes new methylation patterns on previously unmethylated DNA, particularly in embryonic stem cells. This function is essential for silencing genes that should not be expressed in certain cell types, thereby maintaining cellular identity and function. The ability of Dnmt3b to add methyl groups to cytosines within CpG dinucleotides is critical for proper regulation of gene expression, and dysregulation of this process can lead to various diseases, including cancer.