P11388

Topoisomerase IIα also known as Topo IIα is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. Topoisomerase IIα plays a critical role in regulating the topological state of DNA, facilitating vital cellular processes including DNA replication, transcription, and chromosome segregation. By introducing transient double-strand breaks and subsequently rejoining DNA strands, Topoisomerase IIα alleviates DNA supercoiling and tangling, thereby maintaining genomic stability and ensuring proper cell division. The functionality of Topoisomerase IIα is particularly important in cell proliferation and has been identified as a key target for numerous anticancer drugs, underscoring its significance in cancer research and therapy.