Q9UD71

DARPP-32 also known as PPP1R1B is a bifunctional signal transduction molecule. DARPP-32 plays a crucial role in dopaminergic signaling pathways, which are vital for numerous brain functions, including motor control, reward processing, and cognitive functions. Located predominantly in neurons that receive dopaminergic input, DARPP-32 acts as a key integrator of dopamine signaling, where phosphorylation state is critical for modulating the activity of protein phosphatase 1, a major enzyme involved in synaptic plasticity and memory formation. Phosphorylation of DARPP-32 on threonine is stimulated by dopamine binding to D1-like receptors, while D2-like receptor activation leads to dephosphorylation, highlighting the intricate balance of signaling pathways that govern neuronal function.