P02649

ApoE(Apolipoprotein E) is a crucial protein found in various cellular locations, including the plasma membrane and cytosol, where ApoE mediates lipid transport and metabolism. The presence of ApoE in plasma lipoproteins is significant for binding, internalization, and breakdown of lipoprotein particles, making ApoE essential for cholesterol and lipid homeostasis. As a ligand for receptors like the LDL receptor and the hepatic apoE receptor, ApoE facilitates the clearance of cholesterol-rich lipoproteins, thus impacting cardiovascular health. ApoE is synthesized in numerous organs, including the liver and brain, and is present in multiple lipoprotein fractions, including VLDL and HDL.