SKU-Pack Size | Availability | Size | Price | |
EAB21628-100UL | In Stock | 100ul | ¥2290.00 | |
EAB21628-200UL | In Stock | 200ul | ¥3690.00 |
Please select the country you are in to find your local distributor. |
![]() |
北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |
Applications | WB, IP, IHC-P, IF/ICC |
Species Reactivity | Human |
Host / Isotype | Rabbit IgG |
Clonality | Monoclonal |
Applications Dilutions | WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 |
MW (kDa) | 61 |
Conjugate | Unconjugate |
Specificity | Chk2 Rabbit Monoclonal Antibody detects endogenous levels of Chk2 protein. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
|
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | Checkpoint kinase 2; CDS1; CHK2; LFS2; RAD53; TPDS4; hCds1; HuCds1; PP1425; CHEK2 |
Gene Aliases | CHEK2 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
Chk2(Checkpoint kinase 2) also known as CHEK2 plays a critical role in the cellular response to DNA damage, functioning as a key regulator in the G2 DNA damage checkpoint. Upon DNA damage, Chk2 is activated and phosphorylates Cdc25C, which inhibits its phosphatase activity, thereby preventing the activation of cyclin-dependent kinases and blocking the progression of mitosis. This mechanism is vital for maintaining genomic stability, as it allows the cell time to repair DNA before division, thus preventing the propagation of damaged DNA. Additionally, Chk2 interacts with various proteins involved in the DNA damage response, including p53, further underscoring its importance in tumor suppression and cellular integrity. |
Product Image Gallery | |
![]() Western blot analysis of extracts on Hela, 293T cells, using Chk2 Rabbit Monoclonal Antibody (EAB21628) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
Specific Protocols | |