SCF also known as KITLG is a hematopoietic growth factor. SCF plays a crucial role as the ligand for the transmembrane tyrosine kinase receptor proto-oncogene c-Kit, which is vital for several cellular processes. SCF is a pleiotropic cytokine that exists in two alternatively spliced forms, consisting of 248 and 220 amino acids in human and mouse systems, respectively. The larger form of SCF is predominantly expressed in fibroblasts, brain, and thymus, while the smaller variant is found in tissues such as the spleen, testis, placenta, and cerebellum. SCF is essential for the development of germ cells, hematopoietic progenitor cells, and melanocyte precursors, as SCF stimulates the proliferation and maturation of both mature and immature mast cells.