P16083 

NQO2 also known as NAD(P)H dehydrogenase quinone 2 is a member of the thioredoxin family of enzymes. NQO2 is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. NQO2 plays a crucial role in cellular defense by catalyzing the reduction of quinones to hydroquinones, thereby detoxifying potentially harmful compounds and protecting cells from oxidative stress, cytotoxicity, and mutagenicity. This 231 amino acid protein is an isozyme of NQO1, differing in its cofactor requirement as NQO2 utilizes dihydronicotinamide riboside (NRH) instead of NAD(P)H, and exhibits unique resistance to common NQO1 inhibitors while being susceptible to quercetin and benzo(a)pyrene. NQO2 is widely expressed across various tissues, with particularly high levels in the liver and testis, and NQO2 expression is induced by environmental toxins such as TCDD.