IkBβ also known as IKBB, NFKBIB is a member of the NF-kappa-B inhibitor family. IkBβ plays a crucial role in regulating the NFkB signaling pathway, which controls immune responses, inflammation, and cell survival. By sequestering NF-κB dimers in the cytoplasm, IkBβ prevents their translocation to the nucleus, thereby inhibiting the transcription of target genes involved in these processes. IkBβ′s importance extends beyond regulatory function; post-translational modifications, such as phosphorylation, can influence stability and interaction with NFkB. These modifications are critical for timely activation and resolution of immune responses, highlighting IkBβ′s significance in maintaining cellular homeostasis and responding to various stimuli.