Q06124 

SHP-2 also known as SH-PTP2, PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. SHP-2 plays a crucial role in cellular signaling by regulating the phosphorylation state of tyrosine residues on proteins, which is essential for controlling various cellular processes such as growth, differentiation, and metabolism. Located primarily in the cytoplasm, SHP-2 interacts with a variety of signaling molecules, including growth factor receptors and other phosphotyrosine-containing proteins, thereby influencing pathways that are vital for cellular responses to external stimuli. The importance of SHP-2 is underscored by its involvement in several diseases, including cancer, where dysregulation of its activity can lead to aberrant signaling and tumor progression. With its ability to modulate key signaling pathways, SHP-2 serves as a significant target for therapeutic intervention and research into cellular mechanisms.