SKU-Pack Size | Availability | Size | Price | |
EAB21705-100UL | In Stock | 100ul | ¥2290.00 |
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北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |
Applications | WB, IP, IF/ICC |
Species Reactivity | Human, Mouse |
Host / Isotype | Rabbit IgG |
Clonality | Monoclonal |
Applications Dilutions | WB=1:500-2000 IP=1:10-100 IF/ICC=1:50-200 |
MW (kDa) | 68 |
Conjugate | Unconjugate |
Specificity | Phospho-SHP-2 (Tyr542) Rabbit Monoclonal Antibody detects endogenous levels of SHP-2 protein only when phosphorylated at Tyr542. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | Protein tyrosine phosphatase non-receptor type 11; CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3; PTPN11 |
Gene Aliases | PTPN11 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
SHP-2 also known as SH-PTP2, PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. SHP-2 plays a crucial role in cellular signaling by regulating the phosphorylation state of tyrosine residues on proteins, which is essential for controlling various cellular processes such as growth, differentiation, and metabolism. Located primarily in the cytoplasm, SHP-2 interacts with a variety of signaling molecules, including growth factor receptors and other phosphotyrosine-containing proteins, thereby influencing pathways that are vital for cellular responses to external stimuli. The importance of SHP-2 is underscored by its involvement in several diseases, including cancer, where dysregulation of its activity can lead to aberrant signaling and tumor progression. With its ability to modulate key signaling pathways, SHP-2 serves as a significant target for therapeutic intervention and research into cellular mechanisms. |
Product Image Gallery | |
![]() Western blot analysis of extracts on NIH/3T3 cells, using Phospho-SHP-2 (Tyr542) Rabbit Monoclonal Antibody (EAB21705) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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Specific Protocols | |