P84077 

ARF1(ADP-ribosylation factor 1) is a member of the human ARF gene family. ARF1 plays a crucial role in cellular processes such as vesicular transport and membrane trafficking, which are vital for maintaining organelle integrity and cellular homeostasis. Located primarily at the Golgi apparatus, ARF1 is involved in the recruitment of coatomer protein complex I (COPI) to membranes, facilitating the formation of transport vesicles. This recruitment is regulated by the binding and hydrolysis of guanosine triphosphate (GTP), highlighting ARF1′s importance in the dynamic regulation of membrane traffic. ARF1′s ability to interact with specific membrane phospholipids further underscores its significance in cellular signaling and transport mechanisms.