Q01201

RelB is a crucial member of the NFκB family of transcription factors. RelB playing a significant role in regulating immune responses, inflammation, and cell survival. RelB is primarily located in the nucleus, where RelB forms heterodimers with other NFκB subunits, such as p50, to bind to specific DNA sequences and activate transcription of target genes. Nuclear localization allows RelB to exert effects on gene expression in response to various stimuli, including cytokines and stress signals. RelB heterodimer formation with p50 enhances transcriptional activity, particularly in promoting the expression of genes involved in immune and inflammatory responses. Additionally, RelB undergoes post-translational modifications, such as phosphorylation, which can influence stability and activity, further underscoring RelB importance in cellular signaling pathways.