Recombinant Antibodies - 14-3-3 sigma Rabbit Monoclonal Antibody

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14-3-3 sigma Rabbit Monoclonal Antibody

Catalog #：EAB21791

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21791-100UL	In Stock	100ul	$343.50

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	EbioCell	Phone：(540) 808-3925
	Imperial Business Park 4819 Emperor Boulevard,	E-mail：order@ebiocell.com
United States	Suite 408 Durham, NC 27703, USA	Web：www.ebiocell.com

Product Information
Applications	WB, IHC-P
Species Reactivity	Human, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-200
MW (kDa)	28
Conjugate	Unconjugate
Specificity	14-3-3 sigma Rabbit Monoclonal Antibody detects endogenous levels of 14-3-3 sigma protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Er; HME1; Mkrn3; Mme1; SFN; YWHAS; 1433S; YWHAS
Gene Aliases	SFN
UniProt ID	P31947
Entrez Gene ID	2810

Product Description

14-3-3 sigma also known as SFN, stratifin, HME1, YWHAS plays a crucial role in cellular signaling and regulation, particularly in cancer biology. 14-3-3 sigma is predominantly expressed in stratified squamous keratinizing epithelium and functions as a secreted adaptor protein that interacts with various target proteins, including Keratin 17. 14-3-3 sigma binding to Keratin 17 enhances the Akt/mTOR signaling pathway, promoting protein synthesis and cell growth, which are vital processes in tumor development and progression. 14-3-3 sigma positively regulates tumor suppressor p53, influencing cell cycle checkpoints and apoptosis. This modulation of key pathways highlights 14-3-3 sigma′s importance in maintaining cellular homeostasis and potential as a therapeutic target in cancer treatment.

Product Image Gallery
Western blot analysis of extracts on A431 cells, using 14-3-3 sigma Rabbit Monoclonal Antibody (EAB21791) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol