Recombinant Antibodies - APC8/Cdc23 Rabbit Monoclonal Antibody

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APC8/Cdc23 Rabbit Monoclonal Antibody

Catalog #：EAB21831

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21831-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	OlaSciences	Phone：+33 (0) 9 77 4001 556
	87, rue des Suisses 65000 Nanterre,	E-mail：ola@olasciences.com
France	France	Web：www.olasciences.com

Product Information
Applications	WB, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IF/ICC=1:50-200
MW (kDa)	69
Conjugate	Unconjugate
Specificity	APC8/Cdc23 Rabbit Monoclonal Antibody detects endogenous levels of APC8/Cdc23 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Cell division cycle 23; APC8; CUT23; ANAPC8; CDC23
Gene Aliases	CDC23
UniProt ID	Q9UJX2
Entrez Gene ID	8697

Product Description

APC8 also known as Cdc23 is a component of the tetratricopeptide repeat (TPR) APC/C sub-complex that also includes APC3 (CDC27) and APC6 (CDC16). APC8 plays a crucial role in the anaphase-promoting complex (APC), which is essential for proper cell cycle progression. APC8 functions as a component of APC that facilitates ubiquitination of mitotic cyclins and other regulatory proteins, promoting sister chromatid separation during metaphase to anaphase transition in mitosis. This process ensures accurate chromosome segregation, which maintains genomic stability and prevents aneuploidy, a condition often associated with cancer. APC8 contains nine tetratricopeptide repeat (TPR) units, which mediate protein-protein interactions, enabling APC to function effectively.

Product Image Gallery
Western blot analysis of extracts on Hela, Jurkat cells, using APC8/Cdc23 Rabbit Monoclonal Antibody (EAB21831) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol