Recombinant Antibodies - MEKK3 Rabbit Monoclonal Antibody

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MEKK3 Rabbit Monoclonal Antibody

Catalog #：EAB21841

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21841-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB, IP, IHC-P, IF/ICC, FC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IP=1:10-100　 IHC-P=1:50-200　 IF/ICC=1:50-200　 FC=1:10-100
MW (kDa)	71
Conjugate	Unconjugate
Specificity	MEKK3 Rabbit Monoclonal Antibody detects endogenous levels of MEKK3 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Mitogen-activated protein kinase kinase kinase 3; MEK Kinase-3; CCM5; MEKK3; MAPKKK3; MAP3K3
Gene Aliases	MAP3K3
UniProt ID	Q99759
Entrez Gene ID	4215

Product Description

MEKK3(MEK kinase 3) also known as MAP3K3 is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. MEKK3 plays a crucial role in mitogen-activated protein (MAP) kinase signaling pathways, which are essential for cellular responses to various extracellular stimuli, including growth factors. Specifically, MEKK3 is involved in phosphorylation and activation of downstream MAP kinases, such as ERK, JNK, and p38, which are pivotal for regulating processes like cell proliferation, differentiation, and survival. Precise regulation of these pathways is vital for maintaining normal cellular functions and preventing diseases such as cancer, where aberrant signaling can lead to uncontrolled cell growth.

Product Image Gallery
Western blot analysis of extracts on A431, 293T cells, using MEKK3 Rabbit Monoclonal Antibody (EAB21841) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol