Q99798

ACO2 also known as Aconitate hydratase, Aconitase 2 is a member of the aconitase/IPM isomerase family. ACO2 plays a crucial role in cellular metabolism by catalyzing the reversible conversion of citrate to isocitrate within the tricarboxylic acid cycle, a key pathway for energy production. This enzyme is predominantly located in the mitochondria, where ACO2 helps maintain a critical citrate:isocitrate ratio, which is essential for various metabolic processes. Proper functioning of ACO2 is vital, as ACO2 not only influences energy production but also impacts the regulation of metabolic intermediates that can affect cell signaling and growth.