Q04771

ACVR1A also known as ACTR-I, ACVR1 plays a crucial role in the signaling pathways of the transforming growth factor beta superfamily, which is essential for regulating various cellular processes such as gene expression, cell differentiation, and morphogenesis. ACVR1A protein interacts with type II receptors to form a heteromeric complex that is vital for the activation of downstream signaling cascades. This interaction is particularly important in the brain, where both receptor types are highly expressed, influencing neural development and function. ACVR1A protein′s ability to mediate distinct effects based on ligand concentration underscores its significance in cellular communication and the potential implications in developmental biology and disease states.