CRCP also known as RPC9, CGRP-RCP is an accessory protein that is expressed in CGRP responsive tissues. CRCP plays a crucial role in the signaling pathways of calcitonin gene-related peptide (CGRP), which is vital for various physiological processes, including the modulation of pain and inflammation. CRCP is primarily located in CGRP-responsive tissues, where CGRP acts as an accessory protein that couples the CGRP receptor to downstream signaling effectors, thereby amplifying the biological effects of CGRP. This interaction is particularly important in reproductive tissues, where CRCP is associated with the acrosome, influencing reproductive functions.