Monoclonal Antibodies - CD22 Mouse Monoclonal Antibody

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CD22 Mouse Monoclonal Antibody

Catalog #：EAB21909

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21909-100UL	In Stock	100ul	￡218.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF/ICC, FC, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500　 IF/ICC=1:100-500　 FC=1:50-200
MW (kDa)	95
Conjugate	Unconjugate
Specificity	CD22 Mouse Monoclonal Antibody detects endogenous levels of CD22 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	B lymphocyte cell adhesion molecule; BLCAM; SIGLEC-2; SIGLEC2; CD22
Gene Aliases	CD22
UniProt ID	P20273
Entrez Gene ID	933

Product Description

CD22 also designated B-lymphocyte cell adhesion molecule (BLCAM), Siglec-2, Leu-14 is a type I integral membrane glycoprotein that plays a crucial role in regulating B cell signaling and maintaining immune homeostasis. CD22 is predominantly expressed on B cells, where CD22 functions as a negative regulator of B cell receptor signaling, thereby preventing excessive activation and promoting self-tolerance. CD22 is located on the cell membrane and is also found in a cytoplasmic form during early stages of B cell development, making CD22 a valuable marker for acute lymphocytic leukemia. Alternative splicing of the CD22 gene results in two isoforms, CD22α and CD22β, with CD22β being more prevalent. CD22 can also exist as a heterodimer composed of CD22β and the shorter CD22α isoform, highlighting the complexity of CD22 regulation and function in the immune response.

Product Image Gallery
Western blot analysis of extracts on Hela, Jurkat, NIH/3T3, HEK293 cells, using CD22 Mouse Monoclonal Antibody (EAB21909) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol