Monoclonal Antibodies - DDB1 Mouse Monoclonal Antibody

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DDB1 Mouse Monoclonal Antibody

Catalog #：EAB21997

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21997-100UL	In Stock	100ul	￡251.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Mouse IgG2a
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　　 IHC-P=1:50-300
MW (kDa)	127
Conjugate	Unconjugate
Specificity	DDB1 Mouse Monoclonal Antibody detects endogenous levels of DDB1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Damage specific DNA binding protein 1; XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1; WHIKERS; DDB1
Gene Aliases	DDB1
UniProt ID	Q16531
Entrez Gene ID	1642

Product Description

DDB1 also known as DDBA is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. DDB1 plays a crucial role in the cellular response to DNA damage, particularly damage caused by ultraviolet light. DDB1 is essential for the recognition and repair of DNA lesions, specifically cyclobutane pyrimidine dimers, which are formed when DNA is exposed to UV radiation. DDB1′s ability to bind to these damaged sites is vital for initiating the nucleotide excision repair pathway, thereby preventing mutations that could lead to skin cancer and other genetic disorders. Mutations in the DDB2 gene, which encodes the other subunit of the DDB complex, are linked to xeroderma pigmentosum group E, a condition characterized by extreme sensitivity to sunlight and a predisposition to skin malignancies.

Product Image Gallery
Western blot analysis of extracts on Hela, HepG2 cells, using DDB1 Mouse Monoclonal Antibody (EAB21997) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol