EYA2 also known as EAB1 is a member of the eyes absent (EYA) family of proteins. EYA2 plays a crucial role in developmental processes, particularly in myogenesis, where Pax3 induces EYA2 in a signaling cascade essential for muscle development. EYA2 features a highly conserved 271 amino acid domain at its carboxy-terminal, which is critical for function as a transcriptional activator, while the amino-terminal region is rich in proline, serine, and threonine residues, contributing to diverse regulatory roles. EYA2 is predominantly expressed in the cytoplasm during late developmental stages in various tissues, including extensor tendons, ligaments, cranial placodes, branchial arches, the central nervous system, and the developing eye. Six proteins facilitate EYA2′s translocation to the nucleus through homeodomain binding, allowing function in connective tissue patterning.