Q13422

Ikaros also known as KIZF1 is a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. Ikaros plays a crucial role in regulating gene expression during lymphocyte development, particularly in T and B cell lineages, by acting as a transcription factor that binds to specific DNA sequences. This function is vital for maintaining proper immune responses and ensuring the differentiation of hematopoietic progenitor cells into functional lymphocytes. Ikaros is primarily expressed in the thymus and spleen, where Ikaros protein is essential for the transcriptional regulation of T cell-specific genes and the commitment of early hematopoietic progenitors to the lymphoid lineage.