LXRα(Liver X receptor alpha) also known as LXRA, NR1H3 is a member of the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. LXRα is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. that heterodimerizes with RXR to regulate transcriptional programs controlling cholesterol efflux, bile acid metabolism, and de novo lipogenesis. LXRα integrates sterol sensing with innate immune signaling, modulating inflammatory gene expression and macrophage polarization through crosstalk with NF-κB and interferon-responsive pathways. Dysregulated LXRα signaling has been associated with cardiometabolic phenotypes, including atherosclerosis-relevant foam cell biology, fatty liver processes, and altered inflammatory responses.