P06239

LcK is a member of the Src family of protein tyrosine kinases (PTKs). Lck plays a crucial role in T cell signaling, particularly in the activation of T cell antigen receptors (TCRs). This activation is vital for the immune response, as it triggers downstream signaling pathways that lead to T cell proliferation, differentiation, and cytokine production. Lck protein is primarily localized in the plasma membrane of T cells, where it associates with the TCR complex, ensuring that it is positioned to effectively transmit signals upon receptor engagement. The human Lck gene is located on chromosome 1p35.1 and encodes a 509 amino acid protein, which is essential for the regulation of immune responses.