Monoclonal Antibodies - TFAM/mtTFA Rabbit Monoclonal Antibody

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TFAM/mtTFA Rabbit Monoclonal Antibody

Catalog #：EAB21978

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21978-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB, IP, IHC-P, IF/ICC
Species Reactivity	Human, Bovine
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IP=1:10-100　 IHC-P=1:100-500　 IF/ICC=1:100-500
MW (kDa)	29
Conjugate	Unconjugate
Specificity	TFAM/mtTFA Rabbit Monoclonal Antibody detects endogenous levels of TFAM/mtTFA protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Mitochondrial transcription factor A; MTDPS15; MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3; TFAM
Gene Aliases	TFAM
UniProt ID	Q00059
Entrez Gene ID	7019

Product Description

mtTFA(mitochondrial transcription factor A) also known as TFAM, TCF6 is a nuclear-encoded protein imported into mitochondria, where mtTFA plays a crucial role in mitochondrial biogenesis by regulating the replication and transcription of mitochondrial DNA (mtDNA). mtTFA function is essential for maintaining mtDNA copy number and integrity, which is vital for proper mitochondrial function and energy production in cells. Alterations in mtTFA expression have been linked to mitochondrial disorders characterized by symptoms like ocular myopathy, exercise intolerance, and muscle wasting, underscoring mtTFA importance in human health. During spermatogenesis in mice and humans, a reduction in mtTFA protein levels leads to decreased mtDNA copy number, which may help prevent paternal mtDNA transmission.

Product Image Gallery
Western blot analysis of extracts on Hela, K562 cells, using TFAM/mtTFA Rabbit Monoclonal Antibody (EAB21978) at 1:2000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Predicted band size: 29 kDa; Observed band size: 24 kDa

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol