P43243

Matrin 3 also known as MATR3 is a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Matrin 3 contains one matrin-type zinc finger and two RNA recognition motif (RRM) domains, which are essential for RNA processing and gene expression regulation. Located primarily in the nucleus, matrin 3 is involved in the formation of the internal fibrogranular network, which provides structural support for nuclear architecture. matrin 3 is particularly important for nuclear retention of defective RNAs, as matrin 3 interacts with the PSF-p54/NRB heteromer complex, thereby preventing the accumulation of faulty transcripts that could lead to cellular dysfunction.