PICK1 is a PDZ-domain containing protein predominantly located in the perinuclear region of cells, where PICK1 plays a crucial role in synaptic transmission and cellular signaling. The localization of PICK1 allows for precise regulation of interactions with other proteins, such as the α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, which is essential for excitatory synaptic transmission. By anchoring AMPA receptors at specific synapses, PICK1 modulates synaptic strength and plasticity, processes vital for learning and memory. Furthermore, PICK1 is phosphorylated in response to protein kinase C alpha (PKCα) activation, highlighting PICK1′s involvement in signaling pathways that regulate cell proliferation and differentiation.