P18065

IGFBP2 is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). IGFBP2 plays a crucial role in regulating insulin-like growth factors (IGFs) by acting as a chaperone that escorts IGFs to target tissues, thereby influencing bioavailability and activity. IGFBP2 is predominantly expressed in several human tissues, including fetal eye and fetal brain, highlighting IGFBP2′s importance during development. IGFBP2′s ability to modulate IGF signaling is vital for various physiological processes, including growth and metabolism, and IGFBP2 dysregulation has been implicated in conditions such as cancer and metabolic disorders. IGFBP2′s interaction with IGFs not only affects distribution but also half-life, making IGFBP2 a key player in IGF signaling pathway.