S100A6(S100 calcium binding protein A6) also known as Calcyclin is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A6 plays a crucial role in calcium signaling pathways. S100A6 is primarily located in the cytoplasm and nucleus of cells, where S100A6 is involved in regulating various cellular processes such as growth, proliferation, and secretion. This localization allows for rapid responses to calcium fluctuations, which are essential for processes like muscle contraction, neurotransmitter release, and cell differentiation. S100A6 is upregulated in proliferating and differentiating cells and is often overexpressed in acute myeloid leukemias, highlighting S100A6′s potential as a biomarker for certain cancers.