Monoclonal Antibodies - TDP43 Mouse Monoclonal Antibody

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TDP43 Mouse Monoclonal Antibody

Catalog #：EAB21987

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21987-100UL	In Stock	100ul	￡284.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF/ICC, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Mouse IgG2a
Clonality	Monoclonal
Applications Dilutions	WB=1:5000-20000　　 IHC-P=1:500-2000　 IF/ICC=1:200-1000
MW (kDa)	45
Conjugate	Unconjugate
Specificity	TDP43 Mouse Monoclonal Antibody detects endogenous levels of TDP43 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	TAR DNA binding protein; ALS10; TDP-43; TARDBP
Gene Aliases	TARDBP
UniProt ID	Q13148
Entrez Gene ID	23435

Product Description

TDP43 also known as TARDBP is a nuclear protein characterized by two RNA recognition motif (RRM) domains, which play a significant role in RNA processing and regulation. TDP43 is essential for binding to TAR DNA sequence motifs of HIV, functioning as a transcriptional repressor that inhibits HIV-1 transcription. TDP43 is involved in splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, highlighting TARDBP′s importance in maintaining proper cellular function. TDP43 is a major component of ubiquitin-positive inclusion bodies, which are associated with various neurodegenerative diseases, suggesting TDP43′s potential role in disease pathogenesis.

Product Image Gallery
Western blot analysis of extracts on Hela, HEK293, SH-SY5Y, HepG2, PC12 cells, using TDP43 Mouse Monoclonal Antibody (EAB21987) at 1:10000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol