Q96QK1

VPS35 also known as MEM3 belongs to is a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. VPS35 is predominantly localized in the cytoplasm and peripheral membrane, highlighting VPS35′s importance in cellular trafficking processes.