PGC1β also known as PERC, PPARGC1B plays a crucial role as a transcriptional coactivator that regulates mitochondrial biogenesis and energy metabolism. PGC1β interacts with key transcription factors such as nuclear respiratory factor-1 (NRF-1), estrogen receptor alpha (ERα), and glucocorticoid receptor (GR), thereby influencing processes like energy expenditure and glucose metabolism. PGC1β is predominantly expressed in tissues with high metabolic activity, including the brain, heart, and skeletal muscle, and expression is modulated by insulin and fatty acids. Notably, PGC1β undergoes post-translational modifications, including phosphorylation and acetylation, which can significantly impact activity and stability, thereby affecting metabolic pathways and potentially contributing to metabolic disorders such as obesity.