IL-2Rβ also known as CD122, IL2RB is a critical component of the interleukin-2 receptor complex, plays a vital role in the immune response by mediating the signaling pathways that promote T cell proliferation and differentiation. IL-2Rβ is primarily located on the surface of T cells, where IL-2Rβ forms a high-affinity receptor complex with the α and γ chains, facilitating the binding of interleukin-2 (IL-2). IL-2Rβ is essential for the activation of T cells, which are crucial for adaptive immunity, and IL-2Rβ dysregulation can lead to immune disorders or impaired immune responses. Additionally, IL-2Rβ is involved in the formation of the IL-4 and IL-7 receptors, highlighting IL-2Rβ importance in various cytokine signaling pathways.