O95049

ZO-3 also known as TJP3 is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. ZO-3 protein plays a crucial role in the formation and maintenance of tight junctions, which are essential for establishing and regulating the paracellular barrier in epithelial and endothelial cells. These tight junctions not only serve as physical barriers to prevent the passage of solutes and pathogens between cells but also play a significant role in cell signaling and maintaining cell polarity. The interaction of ZO-3 with other tight junction proteins, such as occludin and claudins, is vital for proper assembly and function of tight junctions, which in turn influences various physiological processes, including nutrient absorption and immune response.