Q9UPY3

Dicer is a crucial component of the RNA interference pathway, playing a vital role in the processing of small RNA molecules that regulate gene expression. Dicer is primarily located in the cytoplasm of mammalian cells, where Dicer co-localizes with calreticulin in the endoplasmic reticulum, highlighting Dicer′s importance in cellular RNA metabolism. Dicer′s localization allows for efficient processing of precursor microRNAs and short hairpin RNAs into functional small interfering RNAs, which are essential for targeted degradation of homologous mRNAs. Dicer′s ability to cleave RNA precursors into 21-23 base pair double-stranded RNAs is critical for gene expression regulation and maintaining cellular homeostasis.