Polyclonal Antibodies - Phospho-ALK (Tyr1586) Rabbit Polyclonal Antibody

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Phospho-ALK (Tyr1586) Rabbit Polyclonal Antibody

Catalog #：EAB13212

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB13212-30UL	In Stock	30ul	€141.70
EAB13212-100UL	In Stock	100ul	€297.70
EAB13212-200UL	In Stock	200ul	€479.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB, IHC-P, IF
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300　 IF=1:50-300
MW (kDa)	176
Conjugate	Unconjugate
Specificity	Phospho-ALK (Tyr1586) Rabbit Polyclonal Antibody detects endogenous levels of ALK protein only when phosphorylated at Tyr1586.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Anaplastic lymphoma kinase; ALK1; CD246; NBLST3; ALK
Gene Aliases	ALK
UniProt ID	Q9UM73
Entrez Gene ID	238

Product Description

ALK(Anaplastic lymphoma kinase) also known as CD246 is a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. ALK is a receptor tyrosine kinase characterized by its distinct structure, which includes an N-terminal extracellular domain, a single transmembrane helix, and an intracellular kinase domain. This protein plays a crucial role in the development and function of the nervous system by regulating neuronal growth, differentiation, and survival. Additionally, ALK is implicated in various cancers, including anaplastic large cell lymphoma, non-small cell lung cancer, and neuroblastoma, where genetic alterations such as translocations lead to constitutive activation and drive oncogenic signaling pathways.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol