Q12888

53BP1 also known as TP53BP1 is a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. 53BP1 plays a crucial role in the DNA damage response, particularly in the repair of double-strand breaks through non-homologous end joining. This function is vital for maintaining genomic stability and preventing tumorigenesis, as failure to properly repair DNA can lead to mutations and cancer development. 53BP1′s ability to promote cell proliferation through interactions with p202, while also having the potential to induce cell death via binding to Bcl2 and NFκB p65, highlights 53BP1′s dual role in cellular processes. This makes 53BP1 a significant target for research in cancer biology and therapeutic development.