Recombinant Antibodies - 4E-BP1 Rabbit Monoclonal Antibody

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4E-BP1 Rabbit Monoclonal Antibody

Catalog #：EAB21108

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB21108-30UL	In Stock	30ul	￡119.90
EAB13206-100UL	In Stock	100ul	￡218.90

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IP, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IP=1:50-300 IHC-P=1:100-500 IF/ICC=1:100-500
MW (kDa)	13
Conjugate	Unconjugate
Specificity	4E-BP1 Rabbit Monoclonal Antibody detects endogenous levels of 4E-BP1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Eukaryotic translation initiation factor 4E binding protein 1; BP-1; 4EBP1; 4E-BP1; PHAS-I; EIF4EBP1
Gene Aliases	EIF4EBP1
UniProt ID	Q13541
Entrez Gene ID	1978

Product Description

4E-BP1 also known as EIF4EBP1 is a member of a family of translation repressor proteins. 4E-BP1 plays a crucial role in regulating protein synthesis by acting as a translational repressor. 4E-BP1 binds to eukaryotic translation initiation factor 4E (eIF-4E), preventing formation of the eIF-4F complex essential for translation initiation. Phosphorylation of 4E-BP1 by various kinases, such as S6 kinase p70, MAP kinases, or protein kinase C, leads to dissociation from eIF-4E, promoting translation of mRNAs critical for cell growth and proliferation. This regulatory mechanism is particularly important in cancer biology, where dysregulation of protein synthesis can contribute to tumorigenesis. 4E-BP1 also interacts with 4E-BP2, which modulates eIF-4E activity, highlighting the complexity of translational control in cellular processes.

Product Image Gallery
Western blot analysis of extracts on HEK293, Jurkat, NIH/3T3, C6 cells, using 44E-BP1 Rabbit Monoclonal Antibody (EAB21108) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Predicted band size: 13 kDa; Observed band size: 15-20 kDa

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol