P51587

BRCA2 is located primarily in the nucleus, where BRCA2 facilitates the repair of DNA breaks, thereby preventing the accumulation of mutations that can lead to cancer. Nuclear localization of BRCA2 ensures ready availability to interact with other key players in the DNA repair process, such as Rad51. Mutations in the BRCA2 gene can lead to a loss of function, resulting in an increased risk of breast and ovarian cancers due to the inability to effectively repair DNA damage. BRCA2 contains multiple copies of a 70 amino acid motif known as the BRC motif, which is essential for interaction with Rad51, underscoring the intricate relationship between protein structure and function in cancer biology.