P84022

Smad3 also known as LDS3 and MADH3 is a critical intracellular mediator in the Transforming Growth Factor-beta (TGF-β) signaling pathway. Smad3 playing a pivotal role in regulating gene expression related to cell proliferation, differentiation, apoptosis, and extracellular matrix production. By transducing signals from the cell membrane to the nucleus, Smad3 facilitates the transcription of target genes that are essential for maintaining cellular homeostasis and tissue development. Dysregulation of Smad3 activity is implicated in various pathological conditions, including fibrosis, cancer progression, and immune response modulation, making Smad3 a significant target for research and therapeutic intervention.