Q14289

Pyk2 is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. Pyk2 plays a crucial role in cellular signaling, particularly in the central nervous system, where Pyk2 is highly expressed. Pyk2 is involved in the modulation of ion channel function and the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, which are essential for various cellular processes, including growth, differentiation, and response to stress. The activation of Pyk2 occurs rapidly in response to stimuli that elevate intracellular calcium levels, as well as through the action of phorbol esters that activate protein kinase C (PKC) family members. Notably, Pyk2 undergoes significant post-translational modifications, including phosphorylation on tyrosine residues, which are critical for function and regulation. These modifications not only enhance kinase activity but also facilitate interactions with other signaling proteins, thereby amplifying the cellular response to external signals.