NFkB2 p100/p52 is a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). plays a crucial role in the regulation of immune response, cell survival, and inflammation, making NFkB2 p100/p52 an important target for understanding various diseases, including cancer and autoimmune disorders. NFkB2 p100/p52 is generated through the processing of its precursor, p105, and forms heterodimers with other NFκB subunits, such as p65, to activate transcription of target genes. NFkB2 p100/p52 interaction with p65 enhances the transcriptional activity of the NFκB complex, which is vital for the expression of genes involved in immune and inflammatory responses. Understanding NFkB2 p100/p52 function and interactions is essential for elucidating NFkB2 p100/p52 role in pathophysiological processes and developing targeted therapies.