Q99640

MYT1 (myelin transcription factor 1), also designated MTF1, MYTI or PLPB1, is a 1,121 amino acid nuclear protein expressed in neural progenitors and oligodendrocyte lineage cells. MYT1 consists of seven very highly conserved zinc fingers of the C2HC class of zinc finger transcription factors, which are arranged in two widely separated clusters. These two clusters of the DNA binding domain can function independently and recognize the same DNA sequence. MYT1 is thought to be involved in the development of neurons and oligodendrogalia in the central nervous system and in the regulation of endocrine differentiation and function. Myelin repair in periventricular leukomalacia (PVL) regions in developing brain may involve MYT1 activity.