Q96DB2

There are 11 members in the HDAC family that are classified into four classes. Class I HDACs represent homologs of the yeast histone deacetylase RPD3, class II HDACs share strong homology with the yeast histone deacetylase HDA1, class III HDAC are closely related to the yeast SIR2 protein, and class IV HDACs comprises Histone deacetylase 11 (HDAC11)-related enzymes. HDAC11 contains 347 amino acid residues. HDAC11 contains conserved residues in the catalytic core regions shared by both class I and II mammalian HDAC enzymes. Expression of HDAC11 is high in the kidney, heart, brain, skeletal muscle, and testis, and it localizes to the cell nucleus. The human gene encoding for HDAC11 maps to chromosome 3p25.